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  • Title: Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells.
    Author: Li Z, Liu Y, Zhao X, Pan X, Yin R, Huang C, Chen L, Wei Y.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2008 Sep; 140(1):95-102. PubMed ID: 18440692.
    Abstract:
    OBJECTIVES: To observe the anti-tumor activities of honokiol on human ovarian tumor in vitro and in vivo. STUDY DESIGN: Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed. RESULTS: Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth. CONCLUSIONS: Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment.
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