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  • Title: [A comparative study of leptin content in diabetics and obese subjects].
    Author: Sokolova MA, Babadzhanova GIu.
    Journal: Ter Arkh; 2008; 80(3):69-71. PubMed ID: 18441689.
    Abstract:
    AIM: To compare leptin content in morphologically heterogenic group of patients with type 2 diabetes mellitus and obese patients without family history of diabetes. MATERIAL AND METHODS: Leptin concentration was estimated with enzyme immunoassay (Leptin kit Sandwish ELISA, DRG diagnostics GmdH) in 21 patients with type 2 diabetes mellitus (2DM) and 12 obese patients without family history of diabetes. Distribution of patients with a documented diagnosis type 2 diabetes mellitus was conducted with application of instruments for antropometric examination (G.P. Gneupel, Switzerland). Statistic processing was made with the program Statistica 6 using Student's t-criterion. RESULTS: Patients with diabetes mellitus and phenotypical marker of 2DM had the lowest level of leptin (mean leptin level 1.99 ng/ml in males, 11.01 ng/ml in females versus 2DM patients without the marker (mean leptin level 9.16 n/mg in males, 23.56 n/mg in females) and control group (13.86 ng/ ml in males, 22.55 ng/ml in females). CONCLUSION: There is a correlation between leptin concentration and anthropological features of the patients.
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