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  • Title: Ventricular septal rupture complicating acute myocardial infarction: clinical characteristics and contemporary outcome.
    Author: Poulsen SH, Praestholm M, Munk K, Wierup P, Egeblad H, Nielsen-Kudsk JE.
    Journal: Ann Thorac Surg; 2008 May; 85(5):1591-6. PubMed ID: 18442545.
    Abstract:
    BACKGROUND: The objective of this paper was to study the patient characteristics and contemporary short- and long-term outcome in patients with postinfarct ventricular septal rupture. METHODS: Based on patient files and register data we performed a review of 64 consecutive patients with ventricular septal rupture complicating acute myocardial infarction, admitted to our tertiary center. RESULTS: The mean age of the patients was 70 +/- 7. The median time was five days from onset of symptoms to the diagnosis of the ventricular septal rupture. The overall 30-day, one-, and five- year mortalities were 62%, 72%, and 95%, respectively. Medical treated patients (n = 19) had a 30-day mortality of 100%. Among surgically treated patients (n = 45) the survival at one month, one and five years was 71%, 48%, and 32%, respectively. History of hypertension, complicating congestive heart failure, and age were associated with poor outcome. CONCLUSIONS: Despite improvements in medical and interventional techniques the early as well as the long-term prognosis remains poor in this contemporary series.
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