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  • Title: [Effects of antiosteoporotic agents on glucose and lipid metabolism and cardiovascular system].
    Author: Fukai S.
    Journal: Clin Calcium; 2008 May; 18(5):677-84. PubMed ID: 18445888.
    Abstract:
    Cardiovascular disease is the main contributor of mortality among postmenopausal women. Hormone Replacement Therapy (HRT) has been reported to have a beneficial effect on metabolic and vascular factors. Although, randomized clinical trials have questioned the efficacy of HRT in primary and secondary coronary artery disease (CAD) prevention despite confirming the lipid-lowering effect of HRT. As for selective estrogen receptor modulators (SERMs) , the available information suggests a neutral balance on CAD and stroke, and an increase in risk similar to estrogens for venous thromboembolic diseases. Evidence from both basic science and clinical studies supports the protective role of vitamin D beyond its effect on mineral metabolism. Recent studies suggest that Vitamin D improves vascular compliance, and reduces pro-inflammatory cytokines which may contribute to the improved survival observed in retrospective studies examining the outcome of patients treated with activated Vitamin D compared to those who were not.
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