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  • Title: Molecularly imprinted polymers for alpha-tocopherol delivery.
    Author: Puoci F, Cirillo G, Curcio M, Iemma F, Parisi OI, Castiglione M, Picci N.
    Journal: Drug Deliv; 2008 May; 15(4):253-8. PubMed ID: 18446571.
    Abstract:
    Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on alpha -tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for alpha-tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more alpha-tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids.
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