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  • Title: Betahistine: what's new on the agenda?
    Author: Barak N.
    Journal: Expert Opin Investig Drugs; 2008 May; 17(5):795-804. PubMed ID: 18447604.
    Abstract:
    BACKGROUND: Betahistine is an orally administered, centrally acting histamine H(1) receptor agonist with partial H(3) antagonistic activity and no H(2)-binding effects. In the past betahistine was clinically studied mainly as a vasodilator for conditions such as cluster headaches, vascular dementia and Meniere's disease, for which it is still used. In recent years, histamine was found to be a key neurotransmitter in the regulation of feeding behavior. OBJECTIVE: To provide a review of the developmental history and current research interests of betahistine. METHODS: All reports of betahistine use in animals and humans were retrieved and reviewed. RESULTS/CONCLUSION: The unique pharmacologic properties of betahistine point to its potential future use as an antiobesity agent.
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