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  • Title: Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study.
    Author: Leube DT, Weis S, Freymann K, Erb M, Jessen F, Heun R, Grodd W, Kircher TT.
    Journal: Int J Geriatr Psychiatry; 2008 Nov; 23(11):1114-8. PubMed ID: 18449954.
    Abstract:
    OBJECTIVE: The hippocampus is a key area for episodic memory processes. Hippocampal atrophy is a hallmark feature of Alzheimer's disease (AD). We used a new and automatized morphometric technique to better characterize brain atrophy in subjects with different levels of cognitive deficit. METHODS: In this study 21 participants with Mild Cognitive Impairment (MCI), 12 patients with early AD and 29 elderly control subjects were subjected to high resolution MRI and a neuropsychological test battery. Brain volume across participants, measured by voxel-based morphometry (VBM), was correlated with verbal memory capacity, measured with a verbal memory test (VLMT). RESULTS: Atrophy in the anterior hippocampus, the ento- and perirhinal cortex as well as the parahippocampal gyrus, middle temporal gyrus and anterior cingulate cortex correlated closely with episodic memory performance. CONCLUSIONS: These brain areas are known to subserve episodic encoding of verbal material. The data contribute to a better understanding of atrophic brain processes in subjects at risk for AD. A combination of neuropsychological testing and voxel-based morphometry may serve as a diagnostic tool in the future.
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