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  • Title: 2-[N-(X-chlorophenyl)carbamoyl]benzenesulfonamide (with X = 2 and 4).
    Author: Siddiqui WA, Ahmad S, Khan IU, Siddiqui HL, Parvez M.
    Journal: Acta Crystallogr C; 2008 May; 64(Pt 5):o286-9. PubMed ID: 18451489.
    Abstract:
    The structures of 2-[N-(2-chlorophenyl)carbamoyl]benzenesulfonamide and 2-[N-(4-chlorophenyl)carbamoyl]benzenesulfonamide, both C(13)H(11)ClN(2)O(3)S, are stabilized by extensive intra- and intermolecular hydrogen bonds. In both structures, sulfonamide groups are hydrogen bonded via the N and O atoms and form chains of molecules. The carbamoyl groups are also hydrogen bonded, involving the O and N atoms, further strengthening the polymeric chains running along the c and a axes in the 2- and 4-chloro derivatives, respectively. Carbamoylsulfonamide derivatives are novel compounds with a great potential for medicinal applications.
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