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  • Title: Imaging cortical electrical stimulation in vivo: fast intrinsic optical signal versus voltage-sensitive dyes.
    Author: Tsytsarev V, Premachandra K, Takeshita D, Bahar S.
    Journal: Opt Lett; 2008 May 01; 33(9):1032-4. PubMed ID: 18451977.
    Abstract:
    We applied high-temporal-resolution optical imaging utilizing both the fast intrinsic optical signal (fIOS) and voltage-sensitive dyes (VSDs) to observe the spatiotemporal characteristics of rat somatosensory cortex during electrical stimulation. We find that changes in both the fIOS and VSD signals occur rapidly (<30 ms) after the stimulus is applied, suggesting that both membrane depolarization and transmembrane ion movement occur shortly after the stimulus, preceding the more gradual physiological changes in oxygen consumption revealed by the slower component of the intrinsic optical signal. We find that the VSD signal spreads through a much larger area of cortex than the fIOS.
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