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  • Title: [Paradoxical effect of forced inspiration: a new characteristic of asthmatic disease?].
    Author: Gayrard P, Orehek J.
    Journal: Sem Hop; 1976 Jan 23; 52(4):229-32. PubMed ID: 184534.
    Abstract:
    In normal subjects, forced inspiration may dilate the bronchi and be considered as a defence or compensatory reaction in certain cases. In asthma, forced inspiration has the opposite effect. Bronchospasm occurs or becomes worse, usually moderately and transiently, but sometimes to a marked and lasting degree. These reactions may be prevented by anticholinergic and sympathomimetic drugs. They should be avoided and one should thus prohibit the manoeuvres which trigger them off. One should take them into consideration during respiratory function tests. This paradoxical effect of forced inspiration seems to exist to various degrees in most asthmatic patients, it may be considered as a diagnostic sign of asthma.
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