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  • Title: [Streptozotocin and malignant insulinomas. Apropos of the case. Review of the literature].
    Author: Beylot J, Veyret V, Vallat I, Longy M, Moretti G.
    Journal: Sem Hop; 1976 Feb 23; 52(8):489-96. PubMed ID: 184544.
    Abstract:
    In spite of possible toxicity streptozotocin now appears to be the best treatment for malignant islet cell tumour with liver metastases, i.e. inoperable tumours with a poor prognosis either due to extension of the tumour itself or due to hypoglycemic attacks. Out of about 60 patients thus treated, 1 to 2 years survival were obtained. 22 out of 52 patients reported by Broder and Carter are still alive and one may estimate the overall percentage of favourable results at 65%. On the other hand out of another 100 patients treated elsewhere with this antineoplastic agent, only a few cases of carcinoid tumour gave encouraging results. The course of the others was not modified significantly.
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