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  • Title: Ethanol-induced focal cell necrosis via microcirculatory disturbance in the perfused rat liver.
    Author: Oshita M, Sato N, Yoshihara H, Takei Y, Kashio S, Hijioka T, Fukui H, Goto M, Matsunaga T, Okumura S.
    Journal: Alcohol Alcohol Suppl; 1991; 1():317-20. PubMed ID: 1845554.
    Abstract:
    In the perfused rat liver, infusion of ethanol induced an initial increase in portal pressure which is an indicator of vasoconstriction and a subsequent increase in lactic dehydrogenase (LDH) release, which is an indicator of cell damage in a dose-dependent fashion. Simultaneous infusion of sodium nitroprusside, a potent vasodilator, (100 microM) inhibited the increases in portal pressure and LDH release. Focal hepatocellular necrosis evidenced by trypan-blue stained cell nuclei were localized in midzonal and pericentral area of the liver lobules at 60 min after ethanol load. These ethanol-induced microcirculatory disturbance might be involved in the pathogenesis of alcoholic liver disease.
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