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  • Title: Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value.
    Author: Muratori L, Granito A, Muratori P, Pappas G, Bianchi FB.
    Journal: Clin Liver Dis; 2008 May; 12(2):261-76; vii. PubMed ID: 18456179.
    Abstract:
    Antimitochondrial antibodies (AMA) are the serologic cornerstone in the diagnosis of primary biliary cirrhosis (PBC), even if they are not detectable in a proportion of patients, notwithstanding the most sensitive and sophisticated technologies used. To fill in the serologic gap in AMA-negative PBC, there is sound evidence to consider antinuclear antibody (ANA) patterns, such as anti-multiple nuclear dots and anti-membranous/rim-like, as PBC-specific surrogate hallmarks of the disease, and their detection can be considered virtually diagnostic. Furthermore, particular ANA specificities, such as anti-gp210, anti-p62, anticentromere antibodies, and anti-dsDNA, may provide additional diagnostic and prognostic information.
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