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  • Title: Structural basis of DNA quadruplex recognition by an acridine drug.
    Author: Campbell NH, Parkinson GN, Reszka AP, Neidle S.
    Journal: J Am Chem Soc; 2008 May 28; 130(21):6722-4. PubMed ID: 18457389.
    Abstract:
    The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands
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