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  • Title: Pulmonary mechanic and lung histology injury induced by Crotalus durissus terrificus snake venom.
    Author: Nonaka PN, Amorim CF, Paneque Peres AC, E Silva CA, Zamuner SR, Ribeiro W, Cogo JC, Vieira RP, Dolhnikoff M, de Oliveira LV.
    Journal: Toxicon; 2008 Jun 01; 51(7):1158-66. PubMed ID: 18457854.
    Abstract:
    In the present work we investigated the effects of Crotalus durissus terrificus venom (CdtV) on the pulmonary mechanic events [static and dynamic elastance, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)] and histology after intramuscular injection of saline solution (control) or venom (0.6 microg/g). The static and dynamic elastance values were increased significantly after 3 h of venom inoculation, but were reduced at control values in the other periods studied. The DeltaP1 values that correspond to the resistive properties of lung tissue presented a significant increase after 6h of CdtV injection, reducing to basal levels 12h after the venom injection. In DeltaP2 analysis, correspondent to viscoelastic components, an increase occurred 12 h after the venom injection, returning to control values at 24 h. CdtV also caused an increase of leukocytes recruitment (3-24 h) to the airways wall as well as to the lung parenchyma. In conclusion, C. durissus terrificus rattlesnake venom leads to lung injury which is reverted, after 24 h of inoculation.
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