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  • Title: Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
    Author: Schroeder JE, Fischbach PS, Zheng D, McCleskey EW.
    Journal: Neuron; 1991 Jan; 6(1):13-20. PubMed ID: 1846076.
    Abstract:
    Opioids and opiates decrease the duration of action potentials and the amount of neurotransmitter released from sensory neurons. The mu-type opioid receptor, the binding site for morphine, is thought to act exclusively on K+ channels. Here, we show that activation of the mu receptor inhibits Ca2+ channels in rat sensory neurons; the effect is blocked by a mu antagonist and is not mimicked by kappa or delta receptor agonists. Both low-threshold (T-type) and high-threshold Ca2+ currents are partially suppressed. omega-Conotoxin-sensitive and omega-conotoxin-insensitive, high-threshold Ca2+ currents are inhibited. The kinetic effect on high-threshold current is like that caused by diminished rest potential: the transient component is selectively lost, whereas the sustained component is spared.
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