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  • Title: [Mannan-binding lectin and MBL-associated serine protease-2].
    Author: Jørgensen J, Ytting H, Steffensen RM, Nielsen HJ.
    Journal: Ugeskr Laeger; 2008 Apr 21; 170(17):1445-8. PubMed ID: 18462622.
    Abstract:
    In Denmark approximately 3,600 patients are diagnosed with colorectal cancer (CRC) every year. 75-80% of patients may undergo intended curative resection, but the disease recurs in about 40% within five years and the prognosis is poor. Hence, there is a need for biological markers that could be used for detection, evaluation of prognosis, therapy selection and monitoring. The serum proteins of the innate immune system mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are novel biomarkers under validation in CRC. Low preoperative MBL levels are predictive of pneumonia which subsequently is associated with poor survival. High MASP-2 levels predict recurrence and poor survival.
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