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  • Title: [The coexistence of the impaired exercise tolerance in patients with obstructive sleep apnea with gastroesophageal reflux].
    Author: Hawryłkiewicz I, Dziedzic D, Pływaczewski R, Górecka D.
    Journal: Pneumonol Alergol Pol; 2008; 76(2):83-7. PubMed ID: 18464222.
    Abstract:
    INTRODUCTION: Gastroesophageal reflux (GERD) is a frequent disease in patients with obstructive sleep apnea (OSA). The aim of the study was to evaluate possible correlation between the impairement of exercise tolerance and GERD. MATERIAL AND METHODS: We examined 18 patients with OSA, mean AHI - 44 +/- 22; 6 females, 12 males, mean age 55 +/- 9 years. All patients were treated for metabolic disorders and for hypertension or coronary artery disease. In all patients gastroscopy was performed with 24h pHmetry and 6MWT. RESULTS: In 12 patients GERD was found, in 14 patients esophagitis was diagnosed (among them there were 3 patients without GERD). Patients with GERD were younger (53 +/- 7 vs. 59 +/- 11 years) and more obese (BMI - 38 +/- 5 vs. 36 +/- 9 kg/m(2)). During 6MWT the distance covered was shorter (in % of normal values) in GERD subjects: 78 +/- 17 vs. 86 +/- 22%) and desaturation was deeper (91 +/- 3 vs. 94 +/- 3%). CONCLUSIONS: Despite some tendencies the relationship between GERD and impairement of exercise tolerance in OSA patients was not statistically significant. Perhaps study in larger group of subjects will be more reliable.
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