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  • Title: Insulin rapidly increases glycerol-3-phosphate-acyltransferase activity in rat adipocytes.
    Author: Vila MC, Farese RV.
    Journal: Arch Biochem Biophys; 1991 Feb 01; 284(2):366-8. PubMed ID: 1846521.
    Abstract:
    Glycerol-3-phosphate acyltransferase (G3PAT) was activated by insulin in intact rat adipocytes within 1 min: this activation persisted for 10 min, and was due to a decrease in the Km of the enzyme. The addition of insulin to control adipocyte membranes also increased G3PAT activity, and this effect was mimicked by phosphatidylinositol-specific phospholipase C. Cytosol fractions from insulin-treated adipocytes stimulated G3PAT activity of control membranes, suggesting that a soluble mediator is released during insulin action, possibly through activation of a PI-specific PLC.
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