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  • Title: Idiopathic chronic eosinophilic pneumonia in 7 horses.
    Author: Bell SA, Drew CP, Wilson WD, Pusterla N.
    Journal: J Vet Intern Med; 2008; 22(3):648-53. PubMed ID: 18466259.
    Abstract:
    BACKGROUND: Idiopathic chronic eosinophilic pneumonia of horses is incompletely described. OBJECTIVES: To describe the physical examination, clinicopathologic, histopathologic, and radiographic features and response to corticosteroid treatment of idiopathic chronic eosinophilic pneumonia of horses. ANIMALS: Seven horses with eosinophilic pneumonia. METHODS: Retrospective, descriptive study. RESULTS: Anamnesis, clinical signs, and clinicopathologic and radiologic findings in 7 adult horses with histologically confirmed eosinophilic pneumonia were reviewed. The horses were examined for signs of chronic respiratory disease. The horses ranged in age from 8 to 20 years. Significant findings on physical examination included tachypnea and abnormal respiratory sounds. Thoracic radiography revealed severe diffuse interstitial patterns of increased pulmonary density in all horses. There was a predominance of eosinophils in bronchoalveolar lavage fluid (BALF), and 6 of 7 horses had peripheral blood eosinophilia. Lung biopsies revealed eosinophilic infiltrates in all horses. Dexamethasone was administered to 3 horses and resulted in short-term clinical improvement in all three. CONCLUSIONS AND CLINICAL IMPORTANCE: A diagnosis of idiopathic eosinophilic pneumonia should be considered in horses with a history of chronic pulmonary disease, diffuse interstitial pattern of increased pulmonary density on thoracic radiographs, and a predominance of eosinophils in BALF. Horses with this condition may show a temporary response to treatment with dexamethasone.
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