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  • Title: [Preparation and characterization of the monoclonal antibodies to PTD-bcr/abl].
    Author: Chen RA, Liu L, Jiang SS, Liang YM.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2008 May; 24(5):488-90. PubMed ID: 18466710.
    Abstract:
    AIM: To Preparation and characterization the monoclonal antibody (mAb)to PTD-bcr/abl fusion protein. METHODS: The PTD-bcr/abl fusion protein was expressed in E.coli. BALB/c mice were immunized with specific PTD-bcr/abl. The splenic cells of the mice were fused with Sp2/0 mouse myeloma cells. The hybridoma culture supernatants were screened by indirect ELISA. The property of the antibody was identified by Western blot and immunohistochemistry. RESULTS: The PTD-bcr/abl fusion protein and its mAb were obtained. mAb against PTD-bcr/abl displayed strong specifility and high affinity. CONCLUSION: An anti-PTD-bcr/abl fusion protein mAb with high affinity was abtained, which could be applied to the research of PTD-bcr/abl.
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