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  • Title: Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats.
    Author: Sultana S, Ahmed S, Jahangir T.
    Journal: J Ethnopharmacol; 2008 Jun 19; 118(1):1-6. PubMed ID: 18467048.
    Abstract:
    INTRODUCTION: Emblica officinalis L. commonly known as gooseberry, Phyllanthus emblica, Emblica, Indian gooseberry, amla is used in Indian system of medicine for the treatment of liver ailments. AIM AND OBJECTIVES: In the present study, we report that it ameliorates the carcinogenic response as it reverses the histopathological changes and reduces the number of gamma-GT-positive foci induced by Solt Farber protocol in the liver of Wistar rats. MATERIALS AND METHODS: Tumors were induced by initiation with diethylnitrosoamine (DEN) (200 mg/kg body wt., i.p.) followed by promotion with 2-acetylaminoflourine (2-AAF) (0.02%, w/w in diet) for continuous 6 weeks and the animals were subjected to partial hepatectomy on day 21 of initiation. RESULTS: Pretreatment with defatted methanolic fruit extract (100 and 200mg/kg b.w.) of Emblica officinalis showed significant partial recovery of pathological manifestations as compared to DEN and 2-AAF-treated group animals (p<0.001) and suppressed the tumor forming potential of 2-AAF (p<0.05) at both the doses. CONCLUSION: Emblica officinalis has the potential to suppress carcinogen-induced response in rat liver.
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