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  • Title: Effect of bone mineral with or without collagen membrane in ridge dehiscence defects following premolar extraction.
    Author: Kim M, Kim JH, Lee JY, Cho K, Kang SS, Kim G, Lee MJ, Choi SH.
    Journal: In Vivo; 2008; 22(2):231-6. PubMed ID: 18468408.
    Abstract:
    BACKGROUND: The purpose of this investigation was to evaluate the regenerative response to deproteinized porous bovine bone mineral (BM) when used alone or in combination with a bioresorbable porcine-derived bilayer collagen membrane (CM) for alveolar ridge augmentation in dogs. MATERIALS AND METHODS: The mandibular premolars were extracted unilaterally and three ridge defects were induced in six mongrel dogs. Each defect site was randomly assigned to one of the following treatment groups: BM alone (group A), BM in combination with CM (group B), or neither membrane nor bone graft, which served as a control (group C). No adverse events occurred during the experimental period. Dental computed tomography (CT) scans were taken after postoperative periods of 8 and 16 weeks. RESULTS: The percentage of CT-derived bone density in groups A and B was significantly different from that of group C (p < 0.01) at 8 and 16 weeks. The percentage of CT-derived bone density of the dogs in Group B was significantly higher than that of those in group A at 8 and 16 weeks (p < 0.01). Gross evaluation of the 3-dimensional CT reconstruction image of the canine mandibles after 16 weeks of implantation showed that group B had the greatest amount of bone augmentation and excellent thickness of the buccal aspect of the alveolar ridge. CONCLUSION: These results suggest that BM leads to more successful bone regeneration for guided bone regeneration procedures, especially in conjunction with the use of a CM as a barrier in order to promote the regeneration of canine alveolar ridge defects.
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