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  • Title: Hyperbaric oxygen therapy effects on tissue lesions in acute pancreatitis. Experimental study in rats.
    Author: Festugato M, Coelho CP, Fiedler G, Machado FP, Gonçalves MC, Bassani FR, Pierezan PH, Osvaldt AB, Rohde L.
    Journal: JOP; 2008 May 08; 9(3):275-82. PubMed ID: 18469439.
    Abstract:
    OBJECTIVE: To study the effects of hyperbaric oxygen therapy on tissue lesions in an experimental model of acute pancreatitis induced by pancreatic duct ligation. ANIMALS: Forty-eight adult female Wistar rats were randomized into two groups (n=24): control group and hyperbaric oxygen therapy group. INTERVENTION: The second group was treated with a two-hour daily session of hyperbaric oxygen therapy at 2.5 ATA started 6 hours after pancreatic duct ligation. SETTING: The two groups were divided into 3 subgroups of 8 rats each undergoing euthanasia on days 1, 3, and 7 after the acute pancreatitis induction. MAIN OUTCOME MEASURES: The pancreas was evaluated according to the following histopathologic criteria: edema, hemorrhage, acinar necrosis and leukocyte infiltration. RESULTS: Hyperbaric oxygen therapy was efficient in significantly reducing acinar necrosis on the first day (P=0.049) and the foci of hemorrhage on the seventh day (P=0.050). The edema and leukocyte infiltration did not show the expected reduction. CONCLUSION: The utilization of a daily session of hyperbaric oxygen therapy at 2.5 ATA is efficient in reducing the hemorrhage and acinar necrosis but is not sufficient to reduce edema and leukocyte infiltration.
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