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  • Title: Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica.
    Author: Chen JJ, Yang CS, Peng CF, Chen IS, Miaw CL.
    Journal: J Nat Prod; 2008 Jun; 71(6):1016-21. PubMed ID: 18471021.
    Abstract:
    Four new compounds, including two new dihydroagarofuranoid sesquiterpenes, 8-benzoyloxymutangin (1) and 15-acetoxyorbiculin G (2), a new lignan derivative, 9,9'- O-di-(Z)-feruloyl-(-)-secoisolariciresinol (3), and a new benzenoid, 5'-methoxyevofolin B (4), have been isolated from the stem of Microtropis japonica, together with 20 known compounds (5- 24). 3-Ethoxy-4-hydroxybenzaldehyde (5) was identified from a natural source for the first time. The structures of these new compounds were determined through analyses of physical data. 15-Acetoxyorbiculin G (2), celahin C (6), and salasol A (7) exhibit antituberculosis activities (MICs < or = 39.6 microM) against Mycobacterium tuberculosis H 37Rv in vitro.
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