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  • Title: Investigation of MYH14 as a candidate gene in cleft lip with or without cleft palate.
    Author: Martinelli M, Arlotti M, Palmieri A, Scapoli L, Savoia A, Di Stazio M, Pezzetti F, Masiero E, Carinci F.
    Journal: Eur J Oral Sci; 2008 Jun; 116(3):287-90. PubMed ID: 18471249.
    Abstract:
    Clefts of the orofacial region are among the most common facial defects and are caused by abnormal facial development during gestation. Cleft lip with or without cleft palate (CL/P) is a birth defect with a complex etiology resulting from a mixture of genetic and environmental factors. In the present study we considered myosin 14 (MYH14) as a candidate gene for CL/P. This gene codes for the heavy chain of non-muscle myosin IIC (NMMHC-IIC), maps in the OFC3 region, and shares significant homology with myosin 9, a gene that our group has recently seen to be involved in CL/P. A linkage disequilibrium investigation was conducted with six single nucleotide polymorphisms in MYH14 and a sample of 239 CL/P nonsyndromic patients and their parents. Our family-based investigation provided no evidence of association between MYH14 and CL/P alleles. These data do not support the involvement of MYH14 in CL/P among the Italian population.
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