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  • Title: Arginine methylation of hnRNP K enhances p53 transcriptional activity.
    Author: Chen Y, Zhou X, Liu N, Wang C, Zhang L, Mo W, Hu G.
    Journal: FEBS Lett; 2008 May 28; 582(12):1761-5. PubMed ID: 18472002.
    Abstract:
    Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.
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