These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of hyperglycemia in isogeneic islet transplantation: an experimental animal study.
    Author: Nomikos I, Kalogerakos K, Athanasiou E, Plakokefalos E, Sioutopoulou D, Satra M, Vamvakopoulos NC.
    Journal: Exp Clin Endocrinol Diabetes; 2008 Oct; 116(9):558-60. PubMed ID: 18473285.
    Abstract:
    OBJECTIVE: Study the role of hyperglycemia-induced beta cell loss on grafted islet destruction. DESIGN: Male inbred rats were made diabetic by streptozotocin administration and used as islet donors and/or isograft recipients to probe directly the role of hyperglycemia as an important determinant of transplanted islet fate, following exclusion of immune-related causes of islet graft destruction like allograft immunity and disease recurrence. RESULTS: Our studies showed that: a) Hyperglycemia destroyed islet but not pituitary isografts and b) Tight control of normoglycemia by sufficient islet mass engraftment prevented graft damage. CONCLUSION: While sustained hyperglycemia caused destruction of transplanted islet isografts, induction of normoglycemia by transplantation of sufficient islet mass to diabetic recipients had a beneficial long term effect on their functional engraftment.
    [Abstract] [Full Text] [Related] [New Search]