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  • Title: MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature.
    Author: Soler G, Radford I, Meyer C, Marschalek R, Brouzes C, Ghez D, Romana S, Berger R.
    Journal: Cancer Genet Cytogenet; 2008 May; 183(1):53-9. PubMed ID: 18474298.
    Abstract:
    A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.
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