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  • Title: Large cell transformation mimicking regional lymphomatoid papulosis in a patient with mycosis fungoides.
    Author: Nakahigashi K, Ishida Y, Matsumura Y, Kore-Eda S, Ohmori K, Fujimoto M, Yamashita K, Kotani H, Sakurai T, Miyachi Y.
    Journal: J Dermatol; 2008 May; 35(5):283-8. PubMed ID: 18477228.
    Abstract:
    A 57-year-old Japanese man with tumor-stage mycosis fungoides suddenly presented multiple small papules on the right chest. Histopathology of a biopsy specimen from the papules revealed medium-to-large pleomorphic lymphoid cells throughout the entire dermis but not in the epidermis, and the large cells expressed CD30 antigen. These newly-developed papules underwent spontaneous remission in the following 3 months. We reviewed the reported cases of mycosis fungoides, which showed CD30-positive large cell transformation and those of CD30-positive lymphoproliferative disorders associated with mycosis fungoides.
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