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  • Title: Protein S deficiency: a clinical perspective.
    Author: ten Kate MK, van der Meer J.
    Journal: Haemophilia; 2008 Nov; 14(6):1222-8. PubMed ID: 18479427.
    Abstract:
    Protein S (PS) is an extensively studied protein with an important function in the down-regulation of thrombin generation. Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study. A deficiency of PS predisposes subjects to (recurrent) venous thromboembolism (VTE) and foetal loss. However, the conundrum of diagnosing PS deficiency has led to conflicting reports of PS as a risk factor for VTE. In this review, we aim to present a clinical perspective of PS deficiency.
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