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  • Title: Marginal crack after intravitreal bevacizumab for myopic choroidal neovascularization.
    Author: Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tano Y.
    Journal: Acta Ophthalmol; 2009 Jun; 87(4):460-3. PubMed ID: 18479492.
    Abstract:
    PURPOSE: To report new indocyanine green angiographic (ICGA) findings after intravitreal bevacizumab (IVB) for myopic choroidal neovascularization (mCNV). CASES REPORT: Three eyes of three patients with mCNV were examined with fluorescein angiography (FA) and ICGA using Heidelberg Retinal Angiograph 2 and the conventional fundus camera before and after IVB. The cessation of angiographic leakage on FA was achieved in all eyes (100%) after IVB, however the hypofluorescent line delineating the margin of the neovascular tissue appeared in ICGA seemingly according to the contraction of mCNV. It was not detected either on FA or ICGA with the conventional camera. This hypofluorescence line enlarged over the time. CONCLUSION: The contraction-associated hypofluorescence line, namely marginal crack line, indicates the early damage of retinal pigment epithelium and seems to lead to expanding macular chorioretinal atrophy typically seen in mCNV.
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