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  • Title: Identification of 11,13-dihydroxy-14-octadecaenoic acid as a circulating Na+/K(+)-ATPase inhibitor.
    Author: Lichtstein D, Samuelov S, Gati I, Felix AM, Gabriel TF, Deutsch J.
    Journal: J Endocrinol; 1991 Jan; 128(1):71-8. PubMed ID: 1847965.
    Abstract:
    Two digitalis-like compounds (DLC) were purified to homogeneity from bovine plasma. The purification procedure consisted of organic extractions and batch chromatography followed by three subsequent separations using reverse-phase high-performance liquid chromatography. The presence of a DLC in the different fractions was monitored by their ability to inhibit (a) [3H]ouabain binding to rat brain synaptosomes, and (b) microsomal Na+/K(+)-ATPase activity. Using mass spectrometry and nuclear magnetic resonance spectroscopy the structure of one of the DLCs was identified as 11,13-dihydroxy-14-octadecaenoic acid. It is suggested that this new hydroxy, unsaturated, fatty acid derivative may regulate Na+/K(+)-ATPase activity under some physiological and pathological conditions.
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