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  • Title: Vestibular hypersensitivity to sound in superior canal dehiscence: large evoked responses in the legs produce little postural sway.
    Author: Rosengren SM, Halmagyi GM, Colebatch JG.
    Journal: Clin Neurophysiol; 2008 Jul; 119(7):1674-82. PubMed ID: 18479965.
    Abstract:
    OBJECTIVE: Patients with superior canal dehiscence (SCD) typically have enhanced sound-evoked vestibular reflexes, such as vestibulo-collic and vestibulo-ocular reflexes. We wished to investigate whether sound-evoked lower limb EMG responses and postural sway are also enhanced in this condition. METHODS: Eight patients with CT confirmed SCD (11 affected ears) and 8 age-matched normal controls participated. Three sound-evoked responses were measured; vestibulo-collic reflexes (i.e. vestibular-evoked myogenic potentials, VEMPs), lower limb vestibulo-spinal reflexes and body sway (centre of pressure in mm). Sound stimuli were 500 Hz air-conducted tone bursts of varying lengths (VEMPs: 2 ms; vestibulo-spinal: 20 ms; sway: 1s and 200 ms) set at fixed levels above each subject's VEMP threshold. RESULTS: SCD patients had very large VEMP and vestibulo-spinal responses following high intensity stimulation, but at the matched intensity of 15 dB above threshold amplitudes were similar in both SCD patients and controls. The amplitude of both responses increased linearly with increasing stimulus intensity in both groups. Large ( approximately 20mm), stereotyped sway responses were present in only one (atypical) patient with high intensity stimulation. Small ( approximately 2mm) sway responses were present in the remaining patients, and began immediately following the vestibulo-spinal responses. CONCLUSIONS: Despite the presence of large vestibular reflexes, there is usually very little body sway in response to loud sounds in SCD patients. SIGNIFICANCE: Large short-latency vestibulo-spinal reflexes in SCD do not necessarily evoke large sway responses.
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