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  • Title: Chemiluminescence investigation of carbon dioxide-enhanced oxidation of dihydralazine sulfate by peroxynitrite and its application to pharmaceutical analysis.
    Author: Yang XF.
    Journal: Anal Chim Acta; 2008 Jun 02; 616(2):190-5. PubMed ID: 18482603.
    Abstract:
    A weak chemiluminescence (CL) emission was observed upon mixing peroxynitrite (ONOO(-)) with dihydralazine sulfate (DHZS). Further experiments showed that carbonate media could enhance the CL emission significantly. Based on these observations, a novel flow injection CL method for the determination of DHZS is developed. The CL signal is linearly with DHZS concentration in the range of 0.01-3.0 microg mL(-1) with a detection limit of 3.6 ng mL(-1). The method was applied to the analysis of DHZS in pharmaceutical preparations and compared well with the high-performance liquid chromatography (HPLC) method. The CL mechanism is discussed and it is postulated that it involves nitrosoperoxocarboxylate (ONOOCO(2)(-)), which is an unstable adduct and can rapidly decompose into *NO(2) and *CO(3)(-) radical. The latter can then oxidize DHZS to give out strong CL emission.
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