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  • Title: [Prognostic value of the new international staging system in multiple myeloma. Comparison with Durie-Salmon staging system].
    Author: Conté L G, Figueroa M G, Lois V V, Cabrera C ME, León R A, García L H, Rojas R H.
    Journal: Rev Med Chil; 2008 Jan; 136(1):7-12. PubMed ID: 18483648.
    Abstract:
    BACKGROUND: Since 1975, the Durie-Salmon staging system (D&S) has been a widely accepted prognostic classification of multiple myeloma (MM) patients. Recently, the new International Staging System (ISS) was developed using only the values of albumin and beta2-microglobulin. AIM: To compare survival of patients with MM treated in six medical centers in Chile according to the D&S system and the new ISS. MATERIAL AND METHODS: Retrospective analysis of demographic information, clinical features and survival rate of patients treated between 1998 and 2002, and grouped according to both systems. RESULTS: Information of 81 patients aged 38 to 90 years (43 women) was retrieved. According D&S system 11% were in stage I 12% in stage II and 73% in stage III According to ISS, 34% were in stage I 35% in stage II and 31% in stage III Median of survival of all patients was 32 months. Both staging systems had a prognostic value. However, median survival for the three stages of the ISS system was significantly different (67, 29 and 14 months in stages III and III, respectively, p =0.02). Patients in advanced stages II and III of the ISS, had a higher frequency of anemia, hypercalcemia, renal failure and hypoalbuminemia. In stages II and III of ISS the presence of renal failure was associated with a non significantly different lower survival. CONCLUSIONS: The ISS is a simple and effective grouping method for patients with MM, that predicts survival. The presence of renal insufficiency might identify a subgroup of patients included in stages II and III of ISS with a higher mortality.
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