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  • Title: A case of livedoid vasculopathy associated with factor V Leiden mutation: successful treatment with oral warfarin.
    Author: Kavala M, Kocaturk E, Zindanci I, Turkoglu Z, Altintas S.
    Journal: J Dermatolog Treat; 2008; 19(2):121-3. PubMed ID: 18484430.
    Abstract:
    Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions.
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