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  • Title: Influence of interleukin 18 promoter polymorphisms in susceptibility to Kawasaki disease in Taiwan.
    Author: Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, Tsai FJ.
    Journal: J Rheumatol; 2008 Jul; 35(7):1408-13. PubMed ID: 18484687.
    Abstract:
    OBJECTIVE: Proinflammatory cytokines such as interferon-gamma (IFN-gamma) play an important role in the pathogenesis of Kawasaki disease (KD). Interleukin 18 (IL-18) plays a pivotal role in the T helper 1 (Th1)-type response, principally owing to its ability to induce IFN-gamma production. We assessed potential associations between functional IL-18 gene promoter polymorphisms and susceptibility to KD, in addition to clinical features of KD in individuals from Taiwan. METHODS: One hundred forty-six patients with KD and 136 ethnically matched controls from the same geographic area were genotyped for IL-18 -656T/G, -607A/C, and -137C/G promoter polymorphisms. RESULTS: No significant differences in allele and genotype frequencies were found between KD patients and controls for any of the IL-18 polymorphisms investigated. When we compared the overall distribution of haplotype frequencies between KD patients and controls, a significant difference was observed (p <0.0001). In addition, the frequency of the GCG haplotype was significantly higher (p = 0.00001, pc = 0.00004; OR 20.8, 95% CI 3.05-142.3), whereas the frequency of the TAG haplotype was significantly lower in KD patients compared with controls (p = 0.0001, pc = 0.0004; OR 0.35, 95% CI 0.19-0.61). No significant associations were found for comparisons of KD patients to those with and without coronary artery lesions. CONCLUSION: Our results suggest a potential implication of IL-18 promoter polymorphisms in susceptibility to KD in Taiwan.
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