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  • Title: Computational approaches to finding and analyzing cis-regulatory elements.
    Author: Brown CT.
    Journal: Methods Cell Biol; 2008; 87():337-65. PubMed ID: 18485306.
    Abstract:
    The transcription of almost all developmental genes is driven by tissue- and time-specific regulatory elements. These transcriptional regulatory elements lie in the genomic DNA proximal to the gene, and hence are cis-regulatory (as opposed to trans-regulatory elements like transcription factor genes). Over the past three decades, a number of techniques have been applied to the problem of finding and characterizing these regulatory elements. In this chapter, I discuss some computational approaches that have been particularly useful in identifying developmental cis-regulatory regions, and provide a tutorial on how to apply these approaches to the study of chick development.
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