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  • Title: [Predictive index for preeclampsia before conception and primary prevention].
    Author: Emonts P, Seaksan S, Seidel L, Thoumsin H, Brichant JF, Albert A, Foidart JM.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2008 Sep; 37(5):469-76. PubMed ID: 18486359.
    Abstract:
    OBJECTIVE: To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary prevention. MATERIAL AND METHOD: Non-pregnant women with a history of PE (n=101) were compared to non-pregnant parous women with a history of one or more successful normotensive pregnancies (n=50) but with comparable age, gestation and parity profiles. The parameters included history and clinical examination; laboratory studies (hemostasis, coagulation, vitamins); and morphological and functional tests (cardiovascular and renal functions). Stepwise logistic regression analysis was applied to develop a three step PE prediction index based on the most discriminant parameters. Strategies to prevent PE in the high-risk group are described. RESULTS: Identification of women at high risk of PE can be done efficiently (88% sensitivity and specificity) using a predictive index based on a simple history, laboratory, clinical and functional information. Strategies to prevent PE in our high-risk group have given encouraging results during next pregnancy. CONCLUSION: Our study gives a predictive index of PE outside of pregnancy and possibilities to do a primary prevention.
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