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  • Title: Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury.
    Author: Sadasivan S, Dunn WA, Hayes RL, Wang KK.
    Journal: Biochem Biophys Res Commun; 2008 Sep 05; 373(4):478-81. PubMed ID: 18486600.
    Abstract:
    Autophagy has been implicated in several neurodegenerative diseases and recently its role in acute brain injury has received increased interest. In our study, we investigated the profiles of autophagy-linked proteins (MAP-LC3 (Atg8), beclin-1 (Atg6) and the beclin-1-binding protein, bcl-2, following controlled cortical impact injury in rats--a model for moderate-to-severe traumatic brain injury. We observed significant increases in the levels of the processed form of LC3 (LC3-II) in the ipsilateral cortex 2h to 2 days after injury when compared to sham. Furthermore, the beclin-1/bcl-2 ratio in the ipsilateral cortex was found to have increased from 1 and 2 days after injury. Since both of these changes are established autophagy-enabling events, and, based on these data, we propose that autophagy, plays a role in the manifestation of cell injury following brain trauma.
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