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  • Title: Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH).
    Author: Akay MO, Temiz G, Teke HU, Gunduz E, Acikalin MF, Isiksoy S, Durak B, Gulbas Z.
    Journal: Transfus Apher Sci; 2008 Jun; 38(3):189-92. PubMed ID: 18487090.
    Abstract:
    Transfusion associated graft-versus-host disease (TA-GVHD) is a rare, dreadful complication of transfusion in immunocompromized and immunologically competent individuals. The diagnosis is often delayed, because of lack of awareness and the non-specific clinical features. We describe a rapid molecular cytogenetic analysis of FISH for the diagnosis of two cases of TA-GVHD with sex-mismatched donors. The use of FISH is a rapid and sensitive technique for the early diagnosis of TA-GVHD when the recipient and donor are of different gender.
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