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  • Title: [A study of the nucleotide sequence variability of rha locus genes of Yersinia pestis main and non-main subspecies].
    Author: Kukleva LM, Eroshenko GA, Kuklev VE, Shavina NIu, Krasnov IaM, Guseva NP, Kutyrev VV.
    Journal: Mol Gen Mikrobiol Virusol; 2008; (2):23-7. PubMed ID: 18488445.
    Abstract:
    A study of the structural and regulatory genes, determining rhamnose fermentation, that are located in the rha locus of the chromosome of Yersinia pestis main and non-main subspecies and of Yersinia pseudotuberculosis of serogroups I-III was performed. The nucleotide sequence of Y. pestis main subspecies differs substantially from those of non-main subspecies and Y. pseudotuberculosis by the presence of a nucleotide substitution in 671 bp location of rhaS gene resulting presumably in the Y. pestis non-main subsp inability to utilize rhamnose. This results in incapability of Y. pestis non-main subspecies to utilize rhamnose. Other nucleotide substitutions found in Y. pestis non-main subspecies strains influence only upon expression efficiency of this diagnostic criterion.
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