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  • Title: [Endothelioprotective properties of L-arginine in a nitric oxide deficiency model].
    Author: Pokrovskiĭ MV, Pokrovskaia TG, Kochkarov VI, Artiushkova EB.
    Journal: Eksp Klin Farmakol; 2008; 71(2):29-31. PubMed ID: 18488903.
    Abstract:
    In laboratory animals with endothelial dysfunction (nitric oxide deficiency) modeled by the introduction of NO-synthase inhibitor L-NAME, the activation of endothelioprotective effects of enalapril, lozartan, amlodipine, indapamide and nebivolol is revealed for their introduction in combination with L-arginine. This result was confirmed by the behavior of a generalizing parameter, the coefficient of endothelial dysfunction (CED) calculated using the results of tests on endothelium-dependent and -independent vasodilation.
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