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  • Title: [Toxic megacolon secondary to Clostridium difficile-associated pseudomembranous colitis].
    Author: Rasmussen TB, Friis ML, Lehnhoff R, Tøttrup A.
    Journal: Ugeskr Laeger; 2008 May 05; 170(19):1662. PubMed ID: 18489880.
    Abstract:
    A 78-year-old male without pre-existing comorbidity who underwent revision of a hip arthroplasty developed abdominal pain and distension, diarrhoeas, pyrexia and leucocytosis after only 5 days' postoperative treatment with cefuroxime and gentamycine. Abdominal computed tomography demonstrated severe colonic dilation, inflammation and oedema consistent with toxic megacolon. Stool samples were positive for Clostridium difficile. Oral vancomycine treatment and colonic decompression were inefficient. Subtotal colectomy was performed after which the condition improved.
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