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  • Title: The inhibition of restriction endonucleases due to Z-DNA in negatively supercoiled plasmid.
    Author: Lesnik EA, Bes'chetnikova ZhA, Maslova RN, Varshavsky JaM.
    Journal: FEBS Lett; 1991 Mar 11; 280(1):91-3. PubMed ID: 1849100.
    Abstract:
    Plasmid pGC20 containing the (dGC)9 insert in SmaI recognition site has been used to study the inhibition of cleavage by different restriction endonuclease due to Z-DNA formation in (dCG)10 sequence of the negatively supercoiled plasmid. Data obtained indicate the different sensitivity of restriction endonucleases to DNA conformational perturbations resulted from the Z-DNA formation. Therefore, the inhibition of DNA cleavage by a particular restriction endonuclease cannot serve as a criterion for the estimation of the length of B-Z junctions in circular supercoiled DNAs.
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