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  • Title: Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed kinetic resolution of epoxides.
    Author: Elenkov MM, Tang L, Meetsma A, Hauer B, Janssen DB.
    Journal: Org Lett; 2008 Jun 19; 10(12):2417-20. PubMed ID: 18491860.
    Abstract:
    Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones.
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