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  • Title: Lanostane-type triterpenoids from the roots of Kadsura coccinea.
    Author: Wang N, Li Z, Song D, Li W, Fu H, Koike K, Pei Y, Jing Y, Hua H.
    Journal: J Nat Prod; 2008 Jun; 71(6):990-4. PubMed ID: 18491866.
    Abstract:
    Seven new lanostane-type triterpenoids, seco-coccinic acids A-F (1- 6) and coccinilactone A (7), were isolated from the roots of Kadsura coccinea. Their structures were established on the basis of spectroscopic data analysis. The absolute configuration at C-24 of compound 5 was confirmed by the modified Mosher's method. The cell growth inhibitory effects of these compounds were determined in human leukemia HL-60 cells, and it was found that compounds 1, 2, 3, and 5 exhibited antiproliferative effects with GI 50 values ranging from 6.8 to 42.1 microM.
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