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  • Title: Pneumococcal pneumonia in hospitalized Uruguayan children and potential prevention with different vaccine formulations.
    Author: Hortal M, Sehabiague G, Camou T, Iraola I, Estevan M, Pujadas M.
    Journal: J Pediatr; 2008 Jun; 152(6):850-3. PubMed ID: 18492530.
    Abstract:
    OBJECTIVES: To provide information on pneumococcal pneumonias, on their associated serotypes, and to estimate the coverage potentially afforded by antipneumococcal vaccines. STUDY DESIGN: A retrospective study (2000 to 2004) was performed of patients with pneumococcal pneumonia aged 0 to 14 years admitted to the National Reference Children's Hospital in Uruguay. Selected clinical data, radiographic interpretation, and microbiologic reports were obtained for analysis. RESULTS: Of 410 enrolled patients, 384 had consolidated pneumonia/pleural effusion and 26 had infiltrates without consolidation: Pneumococcus was identified in blood or in pleural fluid of 387 patients; 21 serotypes were identified. The most frequent serotypes in decreasing order were serotypes 14, 1, 5, 3, 9V, 6B, and 7F. Forty-eight percent of invasive Streptococcus pneumoniae isolates were obtained from children younger than 24 months. For this group, the 7-valent vaccine would cover 60%, but a 10-valent vaccine would cover 83.8%. CONCLUSIONS: This study provides information on pneumonia of proven S. pneumoniae causes and their associated serotypes, enabling estimation of potential effect of pneumococcal conjugate vaccines.
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