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  • Title: Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells.
    Author: Gilbertson TA, Scobey R, Wilson M.
    Journal: Science; 1991 Mar 29; 251(5001):1613-5. PubMed ID: 1849316.
    Abstract:
    The conduction of calcium ions through glutamate-gated channels is important in the induction of long-term potentiation and may trigger other cellular changes. In retinal bipolar cells, which lack the N-methyl-D-aspartate (NMDA) type of glutamate-gated channel, calcium permeability through non-NMDA channels was examined. Changes in extracellular calcium concentration unexpectedly affected the reversal potential for glutamate-induced currents in a manner consistent with these channels being highly permeable to calcium. External magnesium ions promote desensitization of these non-NMDA channels in a voltage-independent way. Thus, in addition to non-NMDA channels that conduct only sodium and potassium, there is a class that is also permeable to calcium.
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